After updating with PHP 8.0, I get an error 500.
Switching on PHP 7.4, my website is back.
Something is strange because with PHP 80 it works only in wp-admin.
I think the error is from SSL. On Cloudflare, I have the option "FULL" SSL.
It's more likely a plugin/theme issue. Take a look at the domain error log, you'll probably find clues that lead to the culprit.
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