use --wpfc to configure your site to use NGINX Helper for Page Caching
Just to be clear --wpfc configures your site to use Nginx page caching. Nginx Helper is a WordPress plugin (automatically installed by WordOps) to help WordPress selectively clear stale pages from the cache (e.g. the category page when a new post is published).
Too many variables so 'it depends'. The only way to know for sure is to test. So try --wpfc for page caching with Autoptimize to minify (don't combine everything) and see how it performs.